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Researchers found out that participants using this drug for any year, dropped excess weight within a month and have kept the body weight off through the 56 weeks of the study.‎ Contrave is really a combination of the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them more potent and safer.‎ Combo-pilling will be the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties.‎ The biggest reason that employing a combination of pills has become popular will be the fact that as of right now there aren't any long term prescription slimming capsules that have been approved by the FDA aside from orlistat.‎ The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations happen to be rejected or 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bupropion, Contrave comes with a boxed warning to alert medical researchers and patients on the increased chance of suicidal thoughts and behaviors related to antidepressant drugs.‎ The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking.‎ "This may be the first drug I'm aware of that targets the appetite and reward centres inside brain," he explained.‎